The tournament, to be staged this year at Grand Cypress in Orlando, has three qualifiers from each event all season meet in a $1.5 million showdown for a $500,000 top prize at the Eagle course originally designed by Gary Player.
The area already hosts a spot on the 50-and-over Champions Tour and the Franklin Templeton Shootout, a December event hosted by Australian golf legend Greg Norman.
"We are confident that the Naples community will embrace this unique event," Whan said.
The inaugural Titleholders will be staged November 17-20 after the LPGA completes an Asian swing and a stop in Mexico.